Synthesis of Novel Structural Hybrids between Aza-Heterocycles and Azelaic Acid Moiety with a Specific Activity on Osteosarcoma Cells

Nine compounds bearing pyridinyl (or piperidinyl, benzimidazolyl, benzotriazolyl) groups bound to an azelayl moiety through an amide bond were synthesized. The structural analogy with some histone deacetylase inhibitors inspired their syntheses, seeking new selective histone deacetylase inhibitors (...

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Detalles Bibliográficos
Autores principales: Micheletti, Gabriele, Calonghi, Natalia, Farruggia, Giovanna, Strocchi, Elena, Palmacci, Vincenzo, Telese, Dario, Bordoni, Silvia, Frisco, Giulia, Boga, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024557/
https://www.ncbi.nlm.nih.gov/pubmed/31963693
http://dx.doi.org/10.3390/molecules25020404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024557/
https://www.ncbi.nlm.nih.gov/pubmed/31963693
http://dx.doi.org/10.3390/molecules25020404

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