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mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors

BACKGROUND: Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cells remains unclear. The mammalian/mechanistic target of rapamycin (mTOR) and Pol...

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Detalles Bibliográficos
Autores principales: Pan, Yi-Ran, Song, Jing-Yao, Fan, Bin, Wang, Ying, Che, Lin, Zhang, Si-Ming, Chang, Yu-Xin, He, Chang, Li, Guang-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025415/
https://www.ncbi.nlm.nih.gov/pubmed/32066462
http://dx.doi.org/10.1186/s12964-019-0498-0