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Desmetramadol Is Identified as a G-Protein Biased µ Opioid Receptor Agonist
Tramadol is widely used globally and is the second most prescribed opioid in the United States. It treats moderate to severe pain but lethal opioid-induced respiratory depression is uncommon even in large overdose. It is unknown why tramadol spares respiration. Here we show its active metabolite, de...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025522/ https://www.ncbi.nlm.nih.gov/pubmed/32116679 http://dx.doi.org/10.3389/fphar.2019.01680 |