Dissection of the Human T-Cell Receptor γ Gene Repertoire in the Brain and Peripheral Blood Identifies Age- and Alzheimer's Disease-Associated Clonotype Profiles

The immune system contributes to neurodegenerative pathologies. However, the roles of γδ T cells in Alzheimer's disease (AD) are poorly understood. Here, we evaluated somatic variability of T-cell receptor γ genes (TRGs) in patients with AD. We performed deep sequencing of the CDR3 region of TR...

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Detalles Bibliográficos
Autores principales: Aliseychik, Maria, Patrikeev, Anton, Gusev, Fedor, Grigorenko, Anastasia, Andreeva, Tatiana, Biragyn, Arya, Rogaev, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025544/
https://www.ncbi.nlm.nih.gov/pubmed/32117220
http://dx.doi.org/10.3389/fimmu.2020.00012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025544/
https://www.ncbi.nlm.nih.gov/pubmed/32117220
http://dx.doi.org/10.3389/fimmu.2020.00012

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