Heterozygous p53-R280T Mutation Enhances the Oncogenicity of NPC Cells Through Activating PI3K-Akt Signaling Pathway

A heterozygous point mutation of p53 gene at codon 280 from AGA to ACA (R280T) frequently occurs in nasopharyngeal carcinoma (NPC) cell lines, and about 10% NPC tissues. However, the role of this mutation in the pathogenesis of NPC remains unclear. In this study, we generated p53 knockout (KO) NPC c...

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Detalles Bibliográficos
Autores principales: Qin, Zhen-Qi, Li, Qi-Guang, Yi, Hong, Lu, Shan-Shan, Huang, Wei, Rong, Zhuo-Xian, Tang, Yao-Yun, Xiao, Zhi-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025553/
https://www.ncbi.nlm.nih.gov/pubmed/32117754
http://dx.doi.org/10.3389/fonc.2020.00104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025553/
https://www.ncbi.nlm.nih.gov/pubmed/32117754
http://dx.doi.org/10.3389/fonc.2020.00104

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