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Intracochlear Perfusion of Tumor Necrosis Factor-Alpha Induces Sensorineural Hearing Loss and Synaptic Degeneration in Guinea Pigs

Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a prominent role in the nervous system, mediating a range of physiologic and pathologic functions. In the auditory system, elevated levels of TNF-α have been implicated in several types of sensorineural hearing loss, includ...

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Detalles Bibliográficos
Autores principales: Katsumi, Sachiyo, Sahin, Mehmet I., Lewis, Rebecca M., Iyer, Janani S., Landegger, Lukas D., Stankovic, Konstantina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025643/
https://www.ncbi.nlm.nih.gov/pubmed/32116980
http://dx.doi.org/10.3389/fneur.2019.01353