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Variability in estimated gene expression among commonly used RNA-seq pipelines

RNA-sequencing data is widely used to identify disease biomarkers and therapeutic targets using numerical methods such as clustering, classification, regression, and differential expression analysis. Such approaches rely on the assumption that mRNA abundance estimates from RNA-seq are reliable estim...

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Detalles Bibliográficos
Autores principales: Arora, Sonali, Pattwell, Siobhan S., Holland, Eric C., Bolouri, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026138/
https://www.ncbi.nlm.nih.gov/pubmed/32066774
http://dx.doi.org/10.1038/s41598-020-59516-z