Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development

With a five-year survival rate of 9%, pancreatic ductal adenocarcinoma (PDAC) is the deadliest of all cancers. The rapid mortality makes PDAC difficult to research, and inspires a resolve to create reliable, tractable cellular models for preclinical cancer research. Organoids are increasingly used t...

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Detalles Bibliográficos
Autores principales: Nelson, Shannon R., Zhang, Chenxi, Roche, Sandra, O’Neill, Fiona, Swan, Niall, Luo, Yonglun, Larkin, AnneMarie, Crown, John, Walsh, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026166/
https://www.ncbi.nlm.nih.gov/pubmed/32066753
http://dx.doi.org/10.1038/s41598-020-59368-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026166/
https://www.ncbi.nlm.nih.gov/pubmed/32066753
http://dx.doi.org/10.1038/s41598-020-59368-7

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