Investigating surrogate cerebrospinal fluid matrix compositions for use in quantitative LC-MS analysis of therapeutic antibodies in the cerebrospinal fluid

As quantitative analysis of biotherapeutics in cerebrospinal fluid (CSF) with LC-MS becomes increasingly widespread, there is a need for method developments towards higher sensitivity. By using artificial CSF (aCSF) in the development phase, the consumption of costly and sparsely available CSF can b...

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Detalles Bibliográficos
Autores principales: Fogh, Jens Rose, Jacobsen, Anne-Marie, Nguyen, Tam T. T. N., Rand, Kasper D., Olsen, Line Rørbæk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026242/
https://www.ncbi.nlm.nih.gov/pubmed/32008082
http://dx.doi.org/10.1007/s00216-020-02403-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026242/
https://www.ncbi.nlm.nih.gov/pubmed/32008082
http://dx.doi.org/10.1007/s00216-020-02403-3

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