The kinase polypharmacology landscape of clinical PARP inhibitors

Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this is typically done within the same protein class. Four PARP inhibitors have been approved by the FDA as cancer therape...

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Detalles Bibliográficos
Autores principales: Antolin, Albert A., Ameratunga, Malaka, Banerji, Udai, Clarke, Paul A., Workman, Paul, Al-Lazikani, Bissan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026418/
https://www.ncbi.nlm.nih.gov/pubmed/32066817
http://dx.doi.org/10.1038/s41598-020-59074-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026418/
https://www.ncbi.nlm.nih.gov/pubmed/32066817
http://dx.doi.org/10.1038/s41598-020-59074-4

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