A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability

The enterovirus 71 (EV71) 3D(pol) is an RNA-dependent RNA polymerase (RdRP) that plays the central role in the viral genome replication, and is an important target in antiviral studies. Here, we report a crystal structure of EV71 3D(pol) elongation complex (EC) at 1.8 Å resolution. The structure rev...

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Detalles Bibliográficos
Autores principales: Shi, Wei, Ye, Han-Qing, Deng, Cheng-Lin, Li, Rui, Zhang, Bo, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026628/
https://www.ncbi.nlm.nih.gov/pubmed/31863580
http://dx.doi.org/10.1093/nar/gkz1170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026628/
https://www.ncbi.nlm.nih.gov/pubmed/31863580
http://dx.doi.org/10.1093/nar/gkz1170

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