Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models

Genetic heterogeneity within a tumor arises by clonal evolution, and patients with highly heterogeneous tumors are more likely to be resistant to therapy and have reduced survival. Clonal evolution also occurs when a subset of cells leave the primary tumor to form metastases, which leads to reduced...

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Detalles Bibliográficos
Autores principales: Sprouffske, Kathleen, Kerr, Grainne, Li, Cheng, Prahallad, Anirudh, Rebmann, Ramona, Waehle, Verena, Naumann, Ulrike, Bitter, Hans, Jensen, Michael R, Hofmann, Francesco, Brachmann, Saskia M, Ferretti, Stéphane, Kauffmann, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026725/
https://www.ncbi.nlm.nih.gov/pubmed/32099592
http://dx.doi.org/10.1016/j.csbj.2020.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026725/
https://www.ncbi.nlm.nih.gov/pubmed/32099592
http://dx.doi.org/10.1016/j.csbj.2020.01.008

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