Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

[Image: see text] The optimization of a series of benzimidazole–benzoxaborole hybrid molecules linked via a ketone that exhibit good activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river blindness, is described. The lead identified...

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Detalles Bibliográficos
Autores principales: Carter, David S., Jacobs, Robert T., Freund, Yvonne R., Berry, Pamela W., Akama, Tsutomu, Easom, Eric E., Lunde, Christopher S., Rock, Fernando, Stefanakis, Rianna, McKerrow, James, Fischer, Chelsea, Bulman, Christina A., Lim, Kee Chong, Suzuki, Brian M., Tricoche, Nancy, Sakanari, Judy A., Lustigman, Sara, Plattner, Jacob J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026882/
https://www.ncbi.nlm.nih.gov/pubmed/31876143
http://dx.doi.org/10.1021/acsinfecdis.9b00397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026882/
https://www.ncbi.nlm.nih.gov/pubmed/31876143
http://dx.doi.org/10.1021/acsinfecdis.9b00397

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