A small molecule chaperone rescues the stability and activity of a cancer‐associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a human FAD‐dependent enzyme that plays a crucial role in the antioxidant defense system. A naturally occurring single‐nucleotide polymorphism (NQO1*2) in the NQO1 gene leads to an amino acid substitution (P187S), which severely compromises the activity and...

Descripción completa

Detalles Bibliográficos
Autores principales: Strandback, Emilia, Lienhart, Wolf‐Dieter, Hromic‐Jahjefendic, Altijana, Bourgeois, Benjamin, Högler, Anja, Waltenstorfer, Daniel, Winkler, Andreas, Zangger, Klaus, Madl, Tobias, Gruber, Karl, Macheroux, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027498/
https://www.ncbi.nlm.nih.gov/pubmed/31605637
http://dx.doi.org/10.1002/1873-3468.13636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027498/
https://www.ncbi.nlm.nih.gov/pubmed/31605637
http://dx.doi.org/10.1002/1873-3468.13636

Ejemplares similares