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Crucial Roles of Two Hydrated Mg(2+) Ions in Reaction Catalysis of the Pistol Ribozyme
Pistol ribozymes constitute a new class of small self‐cleaving RNAs. Crystal structures have been solved, providing three‐dimensional snapshots along the reaction coordinate of pistol phosphodiester cleavage, corresponding to the pre‐catalytic state, a vanadate mimic of the transition state, and the...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027511/ https://www.ncbi.nlm.nih.gov/pubmed/31804735 http://dx.doi.org/10.1002/anie.201912522 |