Cargando…

The NEDD4‐1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma

E3 ubiquitin ligases primarily determine the substrate specificity of the ubiquitin‐proteasome system and play an essential role in the resistance to bortezomib in multiple myeloma (MM). Neural precursor cell‐expressed developmentally downregulated gene 4‐1 (NEDD4‐1, also known as NEDD4) is a foundi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Xi, Gu, Huiyao, Zhang, Enfan, Chen, Qingxiao, Cao, Wen, Yan, Haimeng, Chen, Jing, Yang, Li, Lv, Ning, He, Jingsong, Yi, Qing, Cai, Zhen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Molecular Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027789/ https://www.ncbi.nlm.nih.gov/pubmed/31390487 http://dx.doi.org/10.1002/ijc.32615

Ejemplares similares

NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma
por: Huang, Xi, et al.
Publicado: (2022)

TRIM21 enhances bortezomib sensitivity in multiple myeloma by halting prosurvival autophagy
por: Chen, Jing, et al.
Publicado: (2023)

The many substrates and functions of NEDD4-1
por: Huang, Xi, et al.
Publicado: (2019)

BAFF is involved in macrophage-induced bortezomib resistance in myeloma
por: Chen, Jing, et al.
Publicado: (2017)

Pirh2 mediates the sensitivity of myeloma cells to bortezomib via canonical NF-κB signaling pathway
por: Yang, Li, et al.
Publicado: (2018)

Therapeutic effects of the novel subtype-selective histone deacetylase inhibitor chidamide on myeloma-associated bone disease
por: He, Jingsong, et al.
Publicado: (2018)

Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways
por: Wu, Xiuhua, et al.
Publicado: (2020)

Chidamide and venetoclax synergistically exert cytotoxicity on multiple myeloma by upregulating BIM expression
por: Cao, Liqin, et al.
Publicado: (2022)

CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma
por: Xu, Ruyi, et al.
Publicado: (2019)

The adverse impact of a gain in chromosome 1q on the prognosis of multiple myeloma treated with bortezomib-based regimens: A retrospective single-center study in China
por: Chen, Qingxiao, et al.
Publicado: (2022)

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases
por: Mund, Thomas, et al.
Publicado: (2018)

Correction: Ubiquitination of alpha-synuclein filaments by Nedd4 ligases
Publicado: (2018)

Metabolic reprogramming in macrophage responses
por: Liu, Yang, et al.
Publicado: (2021)

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays
por: Persaud, Avinash, et al.
Publicado: (2009)

RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways
por: Qu, Jianwei, et al.
Publicado: (2021)

Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis
por: Liu, Yang, et al.
Publicado: (2022)

Interleukin-32α promotes the proliferation of multiple myeloma cells by inducing production of IL-6 in bone marrow stromal cells
por: Lin, Xuanru, et al.
Publicado: (2017)

E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2
por: Li, Hui, et al.
Publicado: (2022)

The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
por: Lumpkin, Ryan J., et al.
Publicado: (2021)

The Role of NEDD4 E3 Ubiquitin–Protein Ligases in Parkinson’s Disease
por: Conway, James A., et al.
Publicado: (2022)

Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination
por: Pak, Youngshil, et al.
Publicado: (2006)

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4
por: Plant, Pamela J., et al.
Publicado: (2009)

NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway
por: den Besten, Willem, et al.
Publicado: (2012)

A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins
por: Milkereit, Ruth, et al.
Publicado: (2011)

The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer
por: Weng, Min, et al.
Publicado: (2017)

E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease
por: Zhang, Ying, et al.
Publicado: (2020)

The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration
por: Haouari, Shanez, et al.
Publicado: (2022)

Expression and regulatory network of E3 ubiquitin ligase NEDD4 family in cancers
por: Cao, Liangzi, et al.
Publicado: (2023)

Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8
por: Yu, Clinton, et al.
Publicado: (2015)

High serum IL-17A is associated with bone destruction in newly diagnosed multiple myeloma patients
por: Dong, Mengmeng, et al.
Publicado: (2022)

Dlg3 Trafficking and Apical Tight Junction Formation Is Regulated by Nedd4 and Nedd4-2 E3 Ubiquitin Ligases
por: Van Campenhout, Claude A., et al.
Publicado: (2011)

Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis
por: Yan, Haimeng, et al.
Publicado: (2019)

The Short Isoform of the Ubiquitin Ligase NEDD4L Is a CREB Target Gene in Hepatocytes
por: Fu, Jingqi, et al.
Publicado: (2013)

The Ubiquitin Ligase Nedd4-1 Participates in Denervation-Induced Skeletal Muscle Atrophy in Mice
por: Nagpal, Preena, et al.
Publicado: (2012)

Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases
por: Koshizuka, Tetsuo, et al.
Publicado: (2018)

Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases
por: Ray, Greeshma, et al.
Publicado: (2019)

Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases
por: Hatstat, A. Katherine, et al.
Publicado: (2021)

Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
por: Xie, Shangdan, et al.
Publicado: (2021)

The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response
por: Lu, Xinxin, et al.
Publicado: (2022)

Elevated intracellular Na(+) and osmolarity stimulate catalytic activity of the ubiquitin ligase Nedd4-2
por: Persaud, Avinash, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3pkjmshr5avbsi9h22n74heirk