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Inherited cardiac diseases, pluripotent stem cells, and genome editing combined—the past, present, and future

Research on mechanisms underlying monogenic cardiac diseases such as primary arrhythmias and cardiomyopathies has until recently been hampered by inherent limitations of heterologous cell systems, where mutant genes are expressed in noncardiac cells, and physiological differences between humans and...

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Detalles Bibliográficos
Autores principales: van den Brink, Lettine, Grandela, Catarina, Mummery, Christine L., Davis, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027796/
https://www.ncbi.nlm.nih.gov/pubmed/31664757
http://dx.doi.org/10.1002/stem.3110