Cargando…

P53 Mutant p53(N236S) Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway

BACKGROUND: Cancer-associated fibroblasts (CAFs) play important roles in cancer development and progression. Recent studies show that p53 plays a cell non-autonomous tumor-suppressive role to restrict tumor growth in CAFs. However, the role of p53 mutant in CAFs remains obscure. METHODS: In this stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Qing, Yu, Biao, Tian, Yingbin, Dan, Juhua, Luo, Ying, Wu, Xiaoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027832/ https://www.ncbi.nlm.nih.gov/pubmed/32104002 http://dx.doi.org/10.2147/OTT.S229065

Ejemplares similares

p53 Mutant p53(N236S) Induces Neural Tube Defects in Female Embryos
por: Zhao, Jinzhi, et al.
Publicado: (2019)

p53N236S Activates Autophagy in Response to Hypoxic Stress Induced by DFO
por: Gao, Kang, et al.
Publicado: (2022)

p53’s Extended Reach: The Mutant p53 Secretome
por: Pavlakis, Evangelos, et al.
Publicado: (2020)

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis
por: Yue, Xuetian, et al.
Publicado: (2016)

Cancer-derived p53 mutants suppress p53-target gene expression—potential mechanism for gain of function of mutant p53
por: Vikhanskaya, Faina, et al.
Publicado: (2007)

p53 tetramerization: at the center of the dominant-negative effect of mutant p53
por: Gencel-Augusto, Jovanka, et al.
Publicado: (2020)

Big bones in p53 mutants
por: LeBrasseur, Nicole
Publicado: (2006)

Mutant p53 succumbs to starvation
por: Moon, Sung-Hwan, et al.
Publicado: (2013)

Chromatin dysregulation by mutant p53
por: Pfister, Neil T., et al.
Publicado: (2016)

Mutant p53 partners in crime
por: Kim, Michael P, et al.
Publicado: (2018)

Mutant p53 in colon cancer
por: Nakayama, Mizuho, et al.
Publicado: (2018)

Editor's Note on ‘Cancer-derived p53 mutants suppress p53-target gene expression—potential mechanism for gain of function of mutant p53’
Publicado: (2023)

Gain-of-Function p53N236S Mutation Drives the Bypassing of HRas(V12)-Induced Cellular Senescence via PGC–1α
por: Yang, Hao, et al.
Publicado: (2023)

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta
por: Madar, Shalom, et al.
Publicado: (2013)

Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53
por: Ghaleb, Amr, et al.
Publicado: (2019)

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
por: Kong, Li Ren, et al.
Publicado: (2020)

Effects of p53 mutants derived from lung carcinomas on the p53-responsive element (p53RE) of the MDM2 gene.
por: Gorgoulis, V. G., et al.
Publicado: (1998)

The aggregation of mutant p53 produces prion-like properties in cancer
por: Rangel, Luciana P, et al.
Publicado: (2014)

The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment
por: Li, Dan-Dan, et al.
Publicado: (2012)

The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12
por: Jia, Shuting, et al.
Publicado: (2012)

Regulation of Mutant p53 Protein Expression
por: Vijayakumaran, Reshma, et al.
Publicado: (2015)

Targeting mutant p53 for cancer therapy
por: Oren, Moshe, et al.
Publicado: (2016)

SNPing away at mutant p53 activities
por: Ortiz, Guadalupe J., et al.
Publicado: (2018)

Mutant p53 as an Antigen in Cancer Immunotherapy
por: Sobhani, Navid, et al.
Publicado: (2020)

Mutant p53 in cell-cell interactions
por: Pilley, Steven, et al.
Publicado: (2021)

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
por: Goh, Amanda M., et al.
Publicado: (2015)

Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties
por: Nakayama, Mizuho, et al.
Publicado: (2020)

Quaternary structure of the specific p53–DNA complex reveals the mechanism of p53 mutant dominance
por: Aramayo, Ricardo, et al.
Publicado: (2011)

Elevation of the TP53 isoform Δ133p53β in glioblastomas: an alternative to mutant p53 in promoting tumor development
por: Kazantseva, Marina, et al.
Publicado: (2018)

p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis
por: Li, Haili, et al.
Publicado: (2019)

Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a “dominant-positive” mechanism
por: Walerych, Dawid, et al.
Publicado: (2018)

Differential regulation of p53 function by the N-terminal ΔNp53 and Δ113p53 isoforms in zebrafish embryos
por: Davidson, William R, et al.
Publicado: (2010)

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant
por: Slatter, T L, et al.
Publicado: (2015)

Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells
por: Ali, Amjad, et al.
Publicado: (2013)

Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
por: Qin, Jiang-Jiang, et al.
Publicado: (2018)

Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC
por: Zhang, Yaqun, et al.
Publicado: (2019)

Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation
por: Na, Bing, et al.
Publicado: (2019)

Δ133p53 is an independent prognostic marker in p53 mutant advanced serous ovarian cancer
por: Hofstetter, G, et al.
Publicado: (2011)

p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53
por: Yan, H, et al.
Publicado: (2015)

A Novel P53-Related Activity in a Colon Adenocarcinoma Cell Line With Mutant P53
por: Gartel, Andrei L., et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_dqm690relg0jfiourdcka1gosd