A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia

Loss‐of‐function genetic variants of triggering receptor expressed on myeloid cells 2 (TREM2) are linked with an enhanced risk of developing dementias. Microglia, the resident immune cell of the brain, express TREM2, and microglial responses are implicated in dementia pathways. In a normal surveilla...

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Detalles Bibliográficos
Autores principales: Piers, Thomas M., Cosker, Katharina, Mallach, Anna, Johnson, Gabriel Thomas, Guerreiro, Rita, Hardy, John, Pocock, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027848/
https://www.ncbi.nlm.nih.gov/pubmed/31907987
http://dx.doi.org/10.1096/fj.201902447R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027848/
https://www.ncbi.nlm.nih.gov/pubmed/31907987
http://dx.doi.org/10.1096/fj.201902447R

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