Stabilization of soluble high‐affinity T‐cell receptor with de novo disulfide bonds

Soluble T‐cell receptors (TCRs) have recently gained visibility as target‐recognition units of anticancer immunotherapeutic agents. Here, we improved the thermal stability of the well‐expressed high‐affinity A6 TCR by introducing pairs of cysteines in the invariable parts of the α‐ and β‐chain. A mu...

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Detalles Bibliográficos
Autores principales: Sádio, Flávio, Stadlmayr, Gerhard, Stadlbauer, Katharina, Gräf, Maximilian, Scharrer, Agnes, Rüker, Florian, Wozniak‐Knopp, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027902/
https://www.ncbi.nlm.nih.gov/pubmed/31552676
http://dx.doi.org/10.1002/1873-3468.13616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027902/
https://www.ncbi.nlm.nih.gov/pubmed/31552676
http://dx.doi.org/10.1002/1873-3468.13616

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