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Allosteric modulation of G protein‐coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?

The function of G protein‐coupled receptors (GPCRs) can be modulated by compounds that bind to other sites than the endogenous orthosteric binding site, so‐called allosteric sites. Structure elucidation of a number of GPCRs has revealed the presence of a sodium ion bound in a conserved allosteric si...

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Detalles Bibliográficos
Autores principales: Massink, Arnault, Amelia, Tasia, Karamychev, Alex, IJzerman, Adriaan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028016/
https://www.ncbi.nlm.nih.gov/pubmed/31495942
http://dx.doi.org/10.1002/med.21633