The Route from the Folded to the Amyloid State: Exploring the Potential Energy Surface of a Drug‐Like Miniprotein

The amyloid formation of the folded segment of a variant of Exenatide (a marketed drug for type‐2 diabetes mellitus) was studied by electronic circular dichroism (ECD) and NMR spectroscopy. We found that the optimum temperature for E5 protein amyloidosis coincides with body temperature and requires...

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Detalles Bibliográficos
Autores principales: Taricska, Nóra, Horváth, Dániel, Menyhárd, Dóra K., Ákontz‐Kiss, Hanna, Noji, Masahiro, So, Masatomo, Goto, Yuji, Fujiwara, Toshimichi, Perczel, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028080/
https://www.ncbi.nlm.nih.gov/pubmed/31647140
http://dx.doi.org/10.1002/chem.201903826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028080/
https://www.ncbi.nlm.nih.gov/pubmed/31647140
http://dx.doi.org/10.1002/chem.201903826

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