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The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1

The TLK1/Nek1 axis contributes to cell cycle arrest and implementation of the DDR to mediate survival upon DNA damage. However, when the damage is too severe, the cells typically are forced into apoptosis, and the contribution of TLKs in this process has not been investigated. In contrast, it is kno...

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Detalles Bibliográficos
Autores principales: Singh, Vibha, Khalil, Md Imtiaz, De Benedetti, Arrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028156/
https://www.ncbi.nlm.nih.gov/pubmed/31914854
http://dx.doi.org/10.1080/15384101.2019.1711317