Cargando…
The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1
The TLK1/Nek1 axis contributes to cell cycle arrest and implementation of the DDR to mediate survival upon DNA damage. However, when the damage is too severe, the cells typically are forced into apoptosis, and the contribution of TLKs in this process has not been investigated. In contrast, it is kno...
Autores principales: | Singh, Vibha, Khalil, Md Imtiaz, De Benedetti, Arrigo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028156/ https://www.ncbi.nlm.nih.gov/pubmed/31914854 http://dx.doi.org/10.1080/15384101.2019.1711317 |
Ejemplares similares
-
Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors
por: Singh, Vibha, et al.
Publicado: (2019) -
TLK1‐mediated MK5‐S354 phosphorylation drives prostate cancer cell motility and may signify distinct pathologies
por: Khalil, Md Imtiaz, et al.
Publicado: (2022) -
The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells
por: Khalil, Md Imtiaz, et al.
Publicado: (2022) -
NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output
por: Khalil, Md Imtiaz, et al.
Publicado: (2020) -
NEK1-Mediated Phosphorylation of YAP1 Is Key to Prostate Cancer Progression
por: Ghosh, Ishita, et al.
Publicado: (2023)