Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells

Mutations in the enzyme isocitrate dehydrogenase 1 (IDH1) lead to metabolic alterations and a sustained formation of 2-hydroxyglutarate (2-HG). 2-HG is an oncometabolite as it inhibits the activity of α-ketoglutarate-dependent dioxygenases such as ten-eleven translocation (TET) enzymes. Inhibitors o...

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Detalles Bibliográficos
Autores principales: Gerecke, Christian, Schumacher, Fabian, Berndzen, Alide, Homann, Thomas, Kleuser, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028341/
https://www.ncbi.nlm.nih.gov/pubmed/31505989
http://dx.doi.org/10.1080/15592294.2019.1666652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028341/
https://www.ncbi.nlm.nih.gov/pubmed/31505989
http://dx.doi.org/10.1080/15592294.2019.1666652

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