PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models

PT-112 is a novel platinum-pyrophosphate conjugate under clinical development for cancer therapy. PT-112 mediates cytostatic and cytotoxic effects against a variety of human and mouse cancer cell lines in vitro. The cytotoxic response to PT-112 is associated with the emission of danger signals under...

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Detalles Bibliográficos
Autores principales: Yamazaki, Takahiro, Buqué, Aitziber, Ames, Tyler D., Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028345/
https://www.ncbi.nlm.nih.gov/pubmed/32117585
http://dx.doi.org/10.1080/2162402X.2020.1721810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028345/
https://www.ncbi.nlm.nih.gov/pubmed/32117585
http://dx.doi.org/10.1080/2162402X.2020.1721810

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