Cargando…

Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

RNA polymerases (RNAPs) contain a conserved ‘secondary channel’ which binds regulatory factors that modulate transcription initiation. In Escherichia coli, the secondary channel factors (SCFs) GreB and DksA both repress ribosomal RNA (rRNA) transcription, but SCF loading and repression mechanisms ar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stumper, Sarah K, Ravi, Harini, Friedman, Larry J, Mooney, Rachel Anne, Corrêa, Ivan R, Gershenson, Anne, Landick, Robert, Gelles, Jeff
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028371/ https://www.ncbi.nlm.nih.gov/pubmed/30720429 http://dx.doi.org/10.7554/eLife.40576

Ejemplares similares

A helicase-tethered ORC flip enables bidirectional helicase loading
por: Gupta, Shalini, et al.
Publicado: (2021)

The elemental mechanism of transcriptional pausing
por: Saba, Jason, et al.
Publicado: (2019)

Synergistic assembly of human pre-spliceosomes across introns and exons
por: Braun, Joerg E, et al.
Publicado: (2018)

Bayesian machine learning analysis of single-molecule fluorescence colocalization images
por: Ordabayev, Yerdos A, et al.
Publicado: (2022)

A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding
por: Champasa, Kanokwan, et al.
Publicado: (2019)

Single molecule analysis reveals reversible and irreversible steps during spliceosome activation
por: Hoskins, Aaron A, et al.
Publicado: (2016)

EDF1 coordinates cellular responses to ribosome collisions
por: Sinha, Niladri K, et al.
Publicado: (2020)

A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution
por: Mohammad, Fuad, et al.
Publicado: (2019)

Visualizing formation of the active site in the mitochondrial ribosome
por: Chandrasekaran, Viswanathan, et al.
Publicado: (2021)

Structure of RNA polymerase bound to ribosomal 30S subunit
por: Demo, Gabriel, et al.
Publicado: (2017)

The dimerization equilibrium of a ClC Cl(−)/H(+) antiporter in lipid bilayers
por: Chadda, Rahul, et al.
Publicado: (2016)

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness
por: Tye, Blake W, et al.
Publicado: (2019)

Gradual compaction of the nascent peptide during cotranslational folding on the ribosome
por: Liutkute, Marija, et al.
Publicado: (2020)

CK1/Doubletime activity delays transcription activation in the circadian clock
por: Top, Deniz, et al.
Publicado: (2018)

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation
por: Steinert, Hannah, et al.
Publicado: (2017)

Ribosome surface properties may impose limits on the nature of the cytoplasmic proteome
por: Schavemaker, Paul E, et al.
Publicado: (2017)

Dynamics of ribosomes and release factors during translation termination in E. coli
por: Adio, Sarah, et al.
Publicado: (2018)

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding
por: Kudva, Renuka, et al.
Publicado: (2018)

Conformational switches control early maturation of the eukaryotic small ribosomal subunit
por: Hunziker, Mirjam, et al.
Publicado: (2019)

Structural and mutational analysis of the ribosome-arresting human XBP1u
por: Shanmuganathan, Vivekanandan, et al.
Publicado: (2019)

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2017)

Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2023)

Elongation inhibitors do not prevent the release of puromycylated nascent polypeptide chains from ribosomes
por: Hobson, Benjamin D, et al.
Publicado: (2020)

Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria
por: Thomas, Erica N, et al.
Publicado: (2020)

Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae
por: Heuer, André, et al.
Publicado: (2017)

The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers
por: Klingauf-Nerurkar, Purnima, et al.
Publicado: (2020)

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors
por: Dennerlein, Sven, et al.
Publicado: (2021)

Cytosolic aspartate aminotransferase moonlights as a ribosome-binding modulator of Gcn2 activity during oxidative stress
por: Crawford, Robert A, et al.
Publicado: (2022)

Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation
por: Smith, Benjamin A, et al.
Publicado: (2013)

Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36
por: van den Heuvel, Jasmin, et al.
Publicado: (2021)

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
por: Juette, Manuel F, et al.
Publicado: (2022)

The gating cycle of a K(+) channel at atomic resolution
por: Cuello, Luis G, et al.
Publicado: (2017)

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling
por: Su, Ting, et al.
Publicado: (2017)

LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection
por: Mattijssen, Sandy, et al.
Publicado: (2017)

Molecular mechanisms of gating in the calcium-activated chloride channel bestrophin
por: Miller, Alexandria N, et al.
Publicado: (2019)

Structures reveal opening of the store-operated calcium channel Orai
por: Hou, Xiaowei, et al.
Publicado: (2018)

Prefabrication of a ribosomal protein subcomplex essential for eukaryotic ribosome formation
por: Peña, Cohue, et al.
Publicado: (2016)

Ribosomes slide on lysine-encoding homopolymeric A stretches
por: Koutmou, Kristin S, et al.
Publicado: (2015)

Mechanistic insights into volatile anesthetic modulation of K2P channels
por: Wague, Aboubacar, et al.
Publicado: (2020)

The fluoride permeation pathway and anion recognition in Fluc family fluoride channels
por: McIlwain, Benjamin C, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t85pjrd0p027cbajs034352uds