A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pul...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028403/ https://www.ncbi.nlm.nih.gov/pubmed/31588083 http://dx.doi.org/10.2169/internalmedicine.3372-19 |
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author | Shima, Natsuki Akiyama, Yoichiro Yamamoto, Shotaro Kokuzawa, Ayako Nagatani, Katsuya Iwamoto, Masahiro Matsubara, Daisuke Kawai, Shigeo Sato, Kojiro Minota, Seiji |
author_facet | Shima, Natsuki Akiyama, Yoichiro Yamamoto, Shotaro Kokuzawa, Ayako Nagatani, Katsuya Iwamoto, Masahiro Matsubara, Daisuke Kawai, Shigeo Sato, Kojiro Minota, Seiji |
author_sort | Shima, Natsuki |
collection | PubMed |
description | A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pulse therapy, intravenous cyclophosphamide pulse therapy, vasodilators, antiplatelet agents, and anticoagulants was not effective. Vasculopathy was progressive, and she presented with gangrene of the toes. She required amputation of her right leg. The pathological findings of the amputated leg revealed thromboangiitis obliterans (TAO). TAO should be considered even in non-smoking women. Non-response to immunosuppressant and anticoagulant therapies may be a clue to the diagnosis of TAO. |
format | Online Article Text |
id | pubmed-7028403 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-70284032020-02-26 A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans Shima, Natsuki Akiyama, Yoichiro Yamamoto, Shotaro Kokuzawa, Ayako Nagatani, Katsuya Iwamoto, Masahiro Matsubara, Daisuke Kawai, Shigeo Sato, Kojiro Minota, Seiji Intern Med Case Report A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pulse therapy, intravenous cyclophosphamide pulse therapy, vasodilators, antiplatelet agents, and anticoagulants was not effective. Vasculopathy was progressive, and she presented with gangrene of the toes. She required amputation of her right leg. The pathological findings of the amputated leg revealed thromboangiitis obliterans (TAO). TAO should be considered even in non-smoking women. Non-response to immunosuppressant and anticoagulant therapies may be a clue to the diagnosis of TAO. The Japanese Society of Internal Medicine 2019-10-07 2020-02-01 /pmc/articles/PMC7028403/ /pubmed/31588083 http://dx.doi.org/10.2169/internalmedicine.3372-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Shima, Natsuki Akiyama, Yoichiro Yamamoto, Shotaro Kokuzawa, Ayako Nagatani, Katsuya Iwamoto, Masahiro Matsubara, Daisuke Kawai, Shigeo Sato, Kojiro Minota, Seiji A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans |
title | A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans |
title_full | A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans |
title_fullStr | A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans |
title_full_unstemmed | A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans |
title_short | A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans |
title_sort | non-smoking woman with anti-phospholipid antibodies proved to have thromboangiitis obliterans |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028403/ https://www.ncbi.nlm.nih.gov/pubmed/31588083 http://dx.doi.org/10.2169/internalmedicine.3372-19 |
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