A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans

A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pul...

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Autores principales: Shima, Natsuki, Akiyama, Yoichiro, Yamamoto, Shotaro, Kokuzawa, Ayako, Nagatani, Katsuya, Iwamoto, Masahiro, Matsubara, Daisuke, Kawai, Shigeo, Sato, Kojiro, Minota, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028403/
https://www.ncbi.nlm.nih.gov/pubmed/31588083
http://dx.doi.org/10.2169/internalmedicine.3372-19
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author Shima, Natsuki
Akiyama, Yoichiro
Yamamoto, Shotaro
Kokuzawa, Ayako
Nagatani, Katsuya
Iwamoto, Masahiro
Matsubara, Daisuke
Kawai, Shigeo
Sato, Kojiro
Minota, Seiji
author_facet Shima, Natsuki
Akiyama, Yoichiro
Yamamoto, Shotaro
Kokuzawa, Ayako
Nagatani, Katsuya
Iwamoto, Masahiro
Matsubara, Daisuke
Kawai, Shigeo
Sato, Kojiro
Minota, Seiji
author_sort Shima, Natsuki
collection PubMed
description A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pulse therapy, intravenous cyclophosphamide pulse therapy, vasodilators, antiplatelet agents, and anticoagulants was not effective. Vasculopathy was progressive, and she presented with gangrene of the toes. She required amputation of her right leg. The pathological findings of the amputated leg revealed thromboangiitis obliterans (TAO). TAO should be considered even in non-smoking women. Non-response to immunosuppressant and anticoagulant therapies may be a clue to the diagnosis of TAO.
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spelling pubmed-70284032020-02-26 A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans Shima, Natsuki Akiyama, Yoichiro Yamamoto, Shotaro Kokuzawa, Ayako Nagatani, Katsuya Iwamoto, Masahiro Matsubara, Daisuke Kawai, Shigeo Sato, Kojiro Minota, Seiji Intern Med Case Report A 48-year-old woman with severe pain and numbness of her right leg and foot was admitted to our hospital. She had never smoked and had little exposure to passive smoking. Initially, polyarteritis nodosa with anti-phospholipid antibodies was considered. Combination therapy with methylprednisolone pulse therapy, intravenous cyclophosphamide pulse therapy, vasodilators, antiplatelet agents, and anticoagulants was not effective. Vasculopathy was progressive, and she presented with gangrene of the toes. She required amputation of her right leg. The pathological findings of the amputated leg revealed thromboangiitis obliterans (TAO). TAO should be considered even in non-smoking women. Non-response to immunosuppressant and anticoagulant therapies may be a clue to the diagnosis of TAO. The Japanese Society of Internal Medicine 2019-10-07 2020-02-01 /pmc/articles/PMC7028403/ /pubmed/31588083 http://dx.doi.org/10.2169/internalmedicine.3372-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shima, Natsuki
Akiyama, Yoichiro
Yamamoto, Shotaro
Kokuzawa, Ayako
Nagatani, Katsuya
Iwamoto, Masahiro
Matsubara, Daisuke
Kawai, Shigeo
Sato, Kojiro
Minota, Seiji
A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
title A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
title_full A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
title_fullStr A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
title_full_unstemmed A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
title_short A Non-smoking Woman with Anti-phospholipid Antibodies Proved to Have Thromboangiitis Obliterans
title_sort non-smoking woman with anti-phospholipid antibodies proved to have thromboangiitis obliterans
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028403/
https://www.ncbi.nlm.nih.gov/pubmed/31588083
http://dx.doi.org/10.2169/internalmedicine.3372-19
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