PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling

Ovarian cancer is the most lethal gynecological malignancies owing to the lack of definitive symptoms until development of widespread metastases. Identification of novel prognostic and therapeutic targets is therefore an urgent need to improve survival. Here, we demonstrated high expression of the m...

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Detalles Bibliográficos
Autores principales: Siu, Michelle K. Y., Jiang, Yu-xin, Wang, Jing-jing, Leung, Thomas H. Y., Ngu, Siew Fei, Cheung, Annie N. Y., Ngan, Hextan Y. S., Chan, Karen K. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028730/
https://www.ncbi.nlm.nih.gov/pubmed/32071289
http://dx.doi.org/10.1038/s41389-020-0209-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028730/
https://www.ncbi.nlm.nih.gov/pubmed/32071289
http://dx.doi.org/10.1038/s41389-020-0209-0

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