Safety, Pharmacokinetics, and Clinical Activity of Adavosertib in Combination with Chemotherapy in Asian Patients with Advanced Solid Tumors: Phase Ib Study

BACKGROUND: The WEE1 inhibitor adavosertib (AZD1775) has been investigated in Western patients. OBJECTIVE: This open-label Phase Ib study (NCT02341456) investigated the safety, pharmacokinetics, and clinical activity of adavosertib in combination with carboplatin alone or paclitaxel plus carboplatin...

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Detalles Bibliográficos
Autores principales: Kato, Hidenori, de Souza, Paul, Kim, Sang-We, Lickliter, Jason D., Naito, Yoichi, Park, Keunchil, Kumar, Sanjeev, Mugundu, Ganesh M., Bang, Yung-Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028795/
https://www.ncbi.nlm.nih.gov/pubmed/32034630
http://dx.doi.org/10.1007/s11523-020-00701-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028795/
https://www.ncbi.nlm.nih.gov/pubmed/32034630
http://dx.doi.org/10.1007/s11523-020-00701-5

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