Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors

Epigenetic reprogramming in Acute Myeloid Leukemia (AML) leads to the aberrant activation of super enhancer (SE) landscapes that drive the expression of key oncogenes, including the oncogenic MYC pathway. These SEs have been identified as promising therapeutic targets, and have given rise to a new c...

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Detalles Bibliográficos
Autores principales: Call, S. Greg, Duren, Ryan P., Panigrahi, Anil K., Nguyen, Loc, Freire, Pablo R., Grimm, Sandra L., Coarfa, Cristian, Conneely, Orla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029036/
https://www.ncbi.nlm.nih.gov/pubmed/32071334
http://dx.doi.org/10.1038/s41598-020-59469-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029036/
https://www.ncbi.nlm.nih.gov/pubmed/32071334
http://dx.doi.org/10.1038/s41598-020-59469-3

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