Cargando…

Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great potential for drug screening applications. However, their usefulness is limited by the relative immaturity of the cells’ electrophysiological properties as compared to native cardiomyocytes in the adult human hea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jæger, Karoline Horgmo, Charwat, Verena, Charrez, Bérénice, Finsberg, Henrik, Maleckar, Mary M., Wall, Samuel, Healy, Kevin E., Tveito, Aslak
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029356/ https://www.ncbi.nlm.nih.gov/pubmed/32116671 http://dx.doi.org/10.3389/fphar.2019.01648

Ejemplares similares

Identifying Drug Response by Combining Measurements of the Membrane Potential, the Cytosolic Calcium Concentration, and the Extracellular Potential in Microphysiological Systems
por: Jæger, Karoline Horgmo, et al.
Publicado: (2021)

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems
por: Tveito, Aslak, et al.
Publicado: (2018)

Heart Muscle Microphysiological System for Cardiac Liability Prediction of Repurposed COVID-19 Therapeutics
por: Charrez, Bérénice, et al.
Publicado: (2021)

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes
por: Jæger, Karoline Horgmo, et al.
Publicado: (2021)

Computational translation of drug effects from animal experiments to human ventricular myocytes
por: Tveito, Aslak, et al.
Publicado: (2020)

In vitro safety “clinical trial” of the cardiac liability of drug polytherapy
por: Charrez, Bérénice, et al.
Publicado: (2021)

Deriving the Bidomain Model of Cardiac Electrophysiology From a Cell-Based Model; Properties and Comparisons
por: Jæger, Karoline Horgmo, et al.
Publicado: (2022)

Efficient, cell-based simulations of cardiac electrophysiology; The Kirchhoff Network Model (KNM)
por: Jæger, Karoline Horgmo, et al.
Publicado: (2023)

The simplified Kirchhoff network model (SKNM): a cell-based reaction–diffusion model of excitable tissue
por: Jæger, Karoline Horgmo, et al.
Publicado: (2023)

Properties of cardiac conduction in a cell-based computational model
por: Jæger, Karoline Horgmo, et al.
Publicado: (2019)

Arrhythmogenic influence of mutations in a myocyte-based computational model of the pulmonary vein sleeve
por: Jæger, Karoline Horgmo, et al.
Publicado: (2022)

A computational method for identifying an optimal combination of existing drugs to repair the action potentials of SQT1 ventricular myocytes
por: Jæger, Karoline Horgmo, et al.
Publicado: (2021)

Nano-scale solution of the Poisson-Nernst-Planck (PNP) equations in a fraction of two neighboring cells reveals the magnitude of intercellular electrochemical waves
por: Jæger, Karoline Horgmo, et al.
Publicado: (2023)

From Millimeters to Micrometers; Re-introducing Myocytes in Models of Cardiac Electrophysiology
por: Jæger, Karoline Horgmo, et al.
Publicado: (2021)

Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction
por: Lee-Montiel, Felipe T., et al.
Publicado: (2021)

Isochoric supercooled preservation and revival of human cardiac microtissues
por: Powell-Palm, Matthew J., et al.
Publicado: (2021)

Unstable eigenmodes are possible drivers for cardiac arrhythmias
por: Tveito, Aslak, et al.
Publicado: (2011)

Organoids and Microphysiological Systems: New Tools for Ophthalmic Drug Discovery
por: Bai, Jing, et al.
Publicado: (2020)

Editorial: Accelerated Translation Using Microphysiological Organoid and Microfluidic Chip Models
por: Benam, Kambez H., et al.
Publicado: (2022)

Stem cell-based vascularization of microphysiological systems
por: Browne, Shane, et al.
Publicado: (2021)

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury
por: Zhou, Yitian, et al.
Publicado: (2019)

Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing
por: Chen, Wei-Yang, et al.
Publicado: (2021)

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application
por: Cairns, Jonathan, et al.
Publicado: (2023)

Conversations about challenges in computing
por: Bruaset, Are, et al.
Publicado: (2013)

A Microphysiological Cell-Culturing System for Pharmacokinetic Drug Exposure and High-Resolution Imaging of Arrays of 3D Microtissues
por: Lohasz, Christian, et al.
Publicado: (2021)

Introduction to partial differential equations: a computational approach
por: Tveito, Aslak, et al.
Publicado: (1998)

Microphysiological systems
por: Hickman, James J., et al.
Publicado: (2019)

Computing characterizations of drugs for ion channels and receptors using Markov models
por: Tveito, Aslak, et al.
Publicado: (2016)

Advanced topics in computational partial differential equations: numerical methods and diffpack programming
por: Langtangen, Hans, et al.
Publicado: (2003)

An Evaluation of the Accuracy of Classical Models for Computing the Membrane Potential and Extracellular Potential for Neurons
por: Tveito, Aslak, et al.
Publicado: (2017)

Simula Research Laboratory
por: Tveito, Aslak
Publicado: (2010)

A Three-Dimensional Engineered Cardiac In Vitro Model: Controlled Alignment of Cardiomyocytes in 3D Microphysiological Systems
por: Navaee, Fatemeh, et al.
Publicado: (2023)

Engineering challenges in microphysiological systems
por: Zhang, Yu Shrike
Publicado: (2017)

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications
por: Mathur, Anurag, et al.
Publicado: (2015)

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
por: Tao, Thi-Phuong, et al.
Publicado: (2023)

Elements of Scientific Computing
por: Tveito, Aslak, et al.
Publicado: (2010)

Numerical methods and software tools in industrial mathematics
por: D√¶hlen, Morten, et al.
Publicado: (1997)

Light-triggered cardiac microphysiological model
por: Vurro, V., et al.
Publicado: (2023)

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development
por: Mathur, Anurag, et al.
Publicado: (2013)

A cell-based framework for modeling cardiac mechanics
por: Telle, Åshild, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d41ceaqq5t8kn4th3n9shjft4o