Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage

Cell-autonomous changes in p53 expression govern the duration and outcome of cell-cycle arrest at the G2 checkpoint for DNA damage. Here, we report that mitogen-activated protein kinase (MAPK) signaling integrates extracellular cues with p53 dynamics to determine cell fate at the G2 checkpoint. Opto...

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Detalles Bibliográficos
Autores principales: De, Siddharth, Campbell, Callum, Venkitaraman, Ashok R., Esposito, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029415/
https://www.ncbi.nlm.nih.gov/pubmed/32075732
http://dx.doi.org/10.1016/j.celrep.2020.01.074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029415/
https://www.ncbi.nlm.nih.gov/pubmed/32075732
http://dx.doi.org/10.1016/j.celrep.2020.01.074

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