The secondary KIT mutation p.Ala510Val in a cutaneous mast cell tumour carrying the activating mutation p.Asn508Ile confers resistance to masitinib in dogs

BACKGROUND: Gain-of-function mutations in KIT are driver events of oncogenesis in mast cell tumours (MCTs) affecting companion animals. Somatic mutations of KIT determine the constitutive activation of the tyrosine kinase receptor leading to a worse prognosis and a shorter survival time than MCTs ha...

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Detalles Bibliográficos
Autores principales: Gentilini, Fabio, Turba, Maria Elena, Dally, Claire, Takanosu, Masamine, Kurita, Sena, Bonkobara, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029481/
https://www.ncbi.nlm.nih.gov/pubmed/32075643
http://dx.doi.org/10.1186/s12917-020-02284-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029481/
https://www.ncbi.nlm.nih.gov/pubmed/32075643
http://dx.doi.org/10.1186/s12917-020-02284-9

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