Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Spinal bulbar muscular atrophy (SBMA) is an adult-onset, slowly progressive motor neuron disease caused by abnormal CAG repeat expansion in the androgen receptor (AR) gene. Although ligand (testosterone)-dependent mutant AR aggregation has been shown to play important roles in motor neuronal degener...

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Detalles Bibliográficos
Autores principales: Onodera, Kazunari, Shimojo, Daisuke, Ishihara, Yasuharu, Yano, Masato, Miya, Fuyuki, Banno, Haruhiko, Kuzumaki, Naoko, Ito, Takuji, Okada, Rina, de Araújo Herculano, Bruno, Ohyama, Manabu, Yoshida, Mari, Tsunoda, Tatsuhiko, Katsuno, Masahisa, Doyu, Manabu, Sobue, Gen, Okano, Hideyuki, Okada, Yohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029484/
https://www.ncbi.nlm.nih.gov/pubmed/32070397
http://dx.doi.org/10.1186/s13041-020-0561-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029484/
https://www.ncbi.nlm.nih.gov/pubmed/32070397
http://dx.doi.org/10.1186/s13041-020-0561-1

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