Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

BACKGROUND: Hexanucleotide repeat expansions of the G(4)C(2) motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues from C9ALS/FTD patients and from mouse models of ALS show RNA foci, dipept...

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Detalles Bibliográficos
Autores principales: Jury, Nur, Abarzua, Sebastian, Diaz, Ivan, Guerra, Miguel V., Ampuero, Estibaliz, Cubillos, Paula, Martinez, Pablo, Herrera-Soto, Andrea, Arredondo, Cristian, Rojas, Fabiola, Manterola, Marcia, Rojas, Adriana, Montecino, Martín, Varela-Nallar, Lorena, van Zundert, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029485/
https://www.ncbi.nlm.nih.gov/pubmed/32070418
http://dx.doi.org/10.1186/s13148-020-0816-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029485/
https://www.ncbi.nlm.nih.gov/pubmed/32070418
http://dx.doi.org/10.1186/s13148-020-0816-9

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