A Pan-Cancer and Polygenic Bayesian Hierarchical Model for the Effect of Somatic Mutations on Survival

We built a novel Bayesian hierarchical survival model based on the somatic mutation profile of patients across 50 genes and 27 cancer types. The pan-cancer quality allows for the model to “borrow” information across cancer types, motivated by the assumption that similar mutation profiles may have si...

Descripción completa

Detalles Bibliográficos
Autores principales: Samorodnitsky, Sarah, Hoadley, Katherine A, Lock, Eric F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029540/
https://www.ncbi.nlm.nih.gov/pubmed/32116467
http://dx.doi.org/10.1177/1176935120907399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029540/
https://www.ncbi.nlm.nih.gov/pubmed/32116467
http://dx.doi.org/10.1177/1176935120907399

Ejemplares similares