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A Pan-Cancer and Polygenic Bayesian Hierarchical Model for the Effect of Somatic Mutations on Survival

We built a novel Bayesian hierarchical survival model based on the somatic mutation profile of patients across 50 genes and 27 cancer types. The pan-cancer quality allows for the model to “borrow” information across cancer types, motivated by the assumption that similar mutation profiles may have si...

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Detalles Bibliográficos
Autores principales:	Samorodnitsky, Sarah, Hoadley, Katherine A, Lock, Eric F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029540/ https://www.ncbi.nlm.nih.gov/pubmed/32116467 http://dx.doi.org/10.1177/1176935120907399

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