Considerations for improved performance of competition association assays analysed with the Motulsky–Mahan's “kinetics of competitive binding” model

BACKGROUND AND PURPOSE: Target engagement dynamics can influence drugs' pharmacological effects. Kinetic parameters for drug:target interactions are often quantified by evaluating competition association experiments—measuring simultaneous protein binding of labelled tracers and unlabelled test...

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Detalles Bibliográficos
Autores principales: Georgi, Victoria, Dubrovskiy, Alexey, Steigele, Stephan, Fernández‐Montalván, Amaury E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029771/
https://www.ncbi.nlm.nih.gov/pubmed/31444916
http://dx.doi.org/10.1111/bph.14841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029771/
https://www.ncbi.nlm.nih.gov/pubmed/31444916
http://dx.doi.org/10.1111/bph.14841

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