Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors

In this study, a drug discovery programme that sought to identify novel dual bacterial topoisomerase II inhibitors (NBTIs) led to the selection of six optimized compounds. In enzymatic assays, the molecules showed equivalent dual-targeting activity against the DNA gyrase and topoisomerase IV enzymes...

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Detalles Bibliográficos
Autores principales: D’Atanasio, Noemi, Capezzone de Joannon, Alessandra, Di Sante, Laura, Mangano, Giorgina, Ombrato, Rosella, Vitiello, Marco, Bartella, Cristina, Magarò, Gabriele, Prati, Federica, Milanese, Claudio, Vignaroli, Carla, Di Giorgio, Francesco Paolo, Tongiani, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029851/
https://www.ncbi.nlm.nih.gov/pubmed/32074119
http://dx.doi.org/10.1371/journal.pone.0228509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029851/
https://www.ncbi.nlm.nih.gov/pubmed/32074119
http://dx.doi.org/10.1371/journal.pone.0228509

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