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The structure of the infectious prion protein: Experimental data and molecular models

The structures of the infectious prion protein, PrP(Sc), and that of its proteolytically truncated variant, PrP 27–30, have evaded experimental determination due to their insolubility and propensity to aggregate. Molecular modeling has been used to fill this void and to predict their structures, but...

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Detalles Bibliográficos
Autores principales: Requena, Jesús R, Wille, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030906/
https://www.ncbi.nlm.nih.gov/pubmed/24583975
http://dx.doi.org/10.4161/pri.28368