Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model

Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic reticulum (SR) ryanodine receptor (RYR) and rapid release of Ca(2+) in the cytoplasm resulting in depression of myocardial function. The aim of...

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Detalles Bibliográficos
Autores principales: Todorova, Valentina K., Siegel, Eric R., Kaufmann, Yihong, Kumarapeli, Asangi, Owen, Aaron, Wei, Jeanne Y., Makhoul, Issam, Klimberg, V. Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031101/
https://www.ncbi.nlm.nih.gov/pubmed/31918212
http://dx.doi.org/10.1016/j.tranon.2019.12.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031101/
https://www.ncbi.nlm.nih.gov/pubmed/31918212
http://dx.doi.org/10.1016/j.tranon.2019.12.006

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