Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure

OBJECTIVE: Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-cell's response to an adverse metabolic...

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Detalles Bibliográficos
Autores principales: Fan, Jason, Du, Wen, Kim-Muller, Ja Young, Son, Jinsook, Kuo, Taiyi, Larrea, Delfina, Garcia, Christian, Kitamoto, Takumi, Kraakman, Michael J., Owusu-Ansah, Edward, Cirulli, Vincenzo, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031142/
https://www.ncbi.nlm.nih.gov/pubmed/32180563
http://dx.doi.org/10.1016/j.molmet.2019.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031142/
https://www.ncbi.nlm.nih.gov/pubmed/32180563
http://dx.doi.org/10.1016/j.molmet.2019.12.008

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