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Controllability analysis of molecular pathways points to proteins that control the entire interaction network

Inputs to molecular pathways that are the backbone of cellular activity drive the cell to certain outcomes and phenotypes. Here, we investigated proteins that topologically controlled different human pathways represented as independent molecular interaction networks, suggesting that a minority of pr...

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Detalles Bibliográficos
Autores principales: Devkota, Prajwal, Wuchty, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031241/
https://www.ncbi.nlm.nih.gov/pubmed/32076007
http://dx.doi.org/10.1038/s41598-020-59717-6