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Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury

The axon initial segment (AIS) cytoskeleton undergoes rapid and irreversible disruption prior to cell death after injury, and loss of AIS integrity can produce profound neurological effects on the nervous system. Here we described a previously unrecognized mechanism for ischemia-induced alterations...

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Detalles Bibliográficos
Autores principales: Zhao, Yanan, Wu, Xuanyuan, Chen, Xin, Li, Jianan, Tian, Cuiping, Chen, Jiangrui, Xiao, Cheng, Zhong, Guisheng, He, Shuijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031317/
https://www.ncbi.nlm.nih.gov/pubmed/32062456
http://dx.doi.org/10.1016/j.isci.2020.100880