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APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destructio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031393/ https://www.ncbi.nlm.nih.gov/pubmed/32076059 http://dx.doi.org/10.1038/s41598-020-59899-z |