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APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes

Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destructio...

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Detalles Bibliográficos
Autores principales:	Parker, Taybor W., Neufeld, Kristi L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031393/ https://www.ncbi.nlm.nih.gov/pubmed/32076059 http://dx.doi.org/10.1038/s41598-020-59899-z

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