Cargando…

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes

Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destructio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parker, Taybor W., Neufeld, Kristi L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031393/ https://www.ncbi.nlm.nih.gov/pubmed/32076059 http://dx.doi.org/10.1038/s41598-020-59899-z

Ejemplares similares

Oncogenic Serine 45-Deleted β-Catenin Remains Susceptible to Wnt Stimulation and APC Regulation in Human Colonocytes
por: Parker, Taybor W., et al.
Publicado: (2020)

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis
por: Cai, Jing, et al.
Publicado: (2015)

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
por: Ranes, Michael, et al.
Publicado: (2021)

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
por: Jung, Youn-Sang, et al.
Publicado: (2020)

Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics
por: Mukherjee, Abhirup, et al.
Publicado: (2018)

α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
por: Choi, Seung H., et al.
Publicado: (2013)

Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
por: Roberts, David M., et al.
Publicado: (2011)

A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient βcatenin destruction
por: Pronobis, Mira I, et al.
Publicado: (2015)

Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission
por: Lach, Ryan S., et al.
Publicado: (2022)

Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex
por: Kunttas-Tatli, Ezgi, et al.
Publicado: (2014)

Modeling Wnt/β-Catenin Target Gene Expression in APC and Wnt Gradients Under Wild Type and Mutant Conditions
por: Benary, Uwe, et al.
Publicado: (2013)

Wnt/β-catenin pathway activation and silencing of the APC gene in HPV-positive human cervical cancer-derived cells
por: Ayala-Calvillo, Erick, et al.
Publicado: (2018)

The utility of Apc-mutant rats in modeling human colon cancer
por: Irving, Amy A., et al.
Publicado: (2014)

The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling
por: Chen, Xi, et al.
Publicado: (2023)

Molecular regulation and pharmacological targeting of the β‐catenin destruction complex
por: van Kappel, Eline C, et al.
Publicado: (2017)

Phase separation of Axin organizes the β-catenin destruction complex
por: Nong, Junxiu, et al.
Publicado: (2021)

Oxidative Distress Induces Wnt/β-Catenin Pathway Modulation in Colorectal Cancer Cells: Perspectives on APC Retained Functions
por: Catalano, Teresa, et al.
Publicado: (2021)

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination
por: Wu, Xiao-Ting, et al.
Publicado: (2021)

Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine
por: Pronobis, Mira I., et al.
Publicado: (2017)

Feedback in the β-catenin destruction complex imparts bistability and cellular memory
por: Cantoria, Mary Jo, et al.
Publicado: (2023)

USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination
por: Novellasdemunt, Laura, et al.
Publicado: (2017)

Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin
por: Erazo-Oliveras, Alfredo, et al.
Publicado: (2023)

β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC
por: Fredericks, Ernst, et al.
Publicado: (2018)

UCHL5 controls β-catenin destruction complex function through Axin1 regulation
por: Han, Wonhee, et al.
Publicado: (2022)

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex
por: Zhao, S-J, et al.
Publicado: (2018)

Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells
por: Barua, Dipak, et al.
Publicado: (2013)

Effects of DCA on Cell Cycle Proteins in Colonocytes
por: Ha, Yun-Hyung, et al.
Publicado: (2010)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis
por: Christie, M, et al.
Publicado: (2013)

Novel association of APC with intermediate filaments identified using a new versatile APC antibody
por: Wang, Yang, et al.
Publicado: (2009)

In vitro effect of uremic serum on barrier function and inflammation in human colonocytes
por: de Andrade, Laila Santos, et al.
Publicado: (2018)

Dynamics of β-Catenin Interactions with APC Protein Regulate Epithelial Tubulogenesis
por: Pollack, Anne L., et al.
Publicado: (1997)

Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling
por: Lin, Chung-Ming, et al.
Publicado: (2017)

Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer
por: Goñi, Francisca J, et al.
Publicado: (2021)

A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression
por: Zeineldin, Maged, et al.
Publicado: (2011)

The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells
por: Yedid, Nofar, et al.
Publicado: (2016)

Functional Comparison of Human Adenomatous Polyposis Coli (APC) and APC-Like in Targeting Beta-Catenin for Degradation
por: Schneikert, Jean, et al.
Publicado: (2013)

Tissue- and stage-specific Wnt target gene expression is controlled subsequent to β-catenin recruitment to cis-regulatory modules
por: Nakamura, Yukio, et al.
Publicado: (2016)

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates
por: Mattes, Benjamin, et al.
Publicado: (2018)

Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo
por: Schaefer, Kristina N., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pre9sg4goj65tqkt1llqugnp3m