A molecular switch regulating transcriptional repression and activation of PPARγ

Nuclear receptor (NR) transcription factors use a conserved activation function-2 (AF-2) helix 12 mechanism for agonist-induced coactivator interaction and NR transcriptional activation. In contrast, ligand-induced corepressor-dependent NR repression appears to occur through structurally diverse mec...

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Detalles Bibliográficos
Autores principales: Shang, Jinsai, Mosure, Sarah A., Zheng, Jie, Brust, Richard, Bass, Jared, Nichols, Ashley, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031403/
https://www.ncbi.nlm.nih.gov/pubmed/32075969
http://dx.doi.org/10.1038/s41467-020-14750-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031403/
https://www.ncbi.nlm.nih.gov/pubmed/32075969
http://dx.doi.org/10.1038/s41467-020-14750-x

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