State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

Membranes are known to have modulatory effects on G protein-coupled receptors (GPCRs) via specific lipid interactions. However, the mechanisms of such modulations in physiological conditions and how they influence GPCR functions remain unclear. Here we report coarse-grained molecular dynamics simula...

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Detalles Bibliográficos
Autores principales: Song, Wanling, Yen, Hsin-Yung, Robinson, Carol V., Sansom, Mark S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031699/
https://www.ncbi.nlm.nih.gov/pubmed/30581046
http://dx.doi.org/10.1016/j.str.2018.10.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031699/
https://www.ncbi.nlm.nih.gov/pubmed/30581046
http://dx.doi.org/10.1016/j.str.2018.10.024

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