Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling

BACKGROUND: The replicative senescence of human dermal fibroblasts (HDFs) is accompanied by growth arrest. In our previous study, the treatment of senescent HDFs with Rg3(S) lowered the intrinsic reactive oxygen species (ROS) levels and reversed cellular senescence by inducing peroxiredoxin-3, an an...

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Detalles Bibliográficos
Autores principales: Yang, Kyeong-Eun, Jang, Hyun-Jin, Hwang, In-Hu, Hong, Eun Mi, Lee, Min-Goo, Lee, Soon, Jang, Ik-Soon, Choi, Jong-Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Pharmacology and physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031753/
https://www.ncbi.nlm.nih.gov/pubmed/32148417
http://dx.doi.org/10.1016/j.jgr.2019.08.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031753/
https://www.ncbi.nlm.nih.gov/pubmed/32148417
http://dx.doi.org/10.1016/j.jgr.2019.08.002

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